Faculty Mentor
Dr. Grace Rossi
Major/Area of Research
Psychology
Description
The Pharmacological and Cognitive Effects of Propranolol on CD-1 Mice Jennifer Hindieh, William Hoefer, Grace Rossi, Christopher McAllister Long Island University Post Campus, Psychology Department, College of Liberal Arts & Sciences Currently, 31 million people in the United States have chronic kidney disease; with high blood pressure being the 2nd leading cause of kidney disease, and about 70 million people in the United States have high blood pressure. The importance of studying the conditions becomes more prevalent as the average individual, of recent times, has a diet consisting of preservatives, artificial ingredients, which in turn leads to a more consistent weight gain over time. For years medical professionals have recommended not only a complete lifestyle change for those that suffer from the aforementioned conditions, but have also prescribed beta-blockers for an even more effective control of high blood pressure. According to Consumer Reports, Propranolol is the 3rd most prescribed beta- blocker in the United States, even though many researchers concluded that the full physiological and cognitive effects are still widely unknown for such a heavily prescribed medication. While the blood pressure benefits of propranolol are for certain, other negative side effects have been reported but not widely studied such as severe cognitive deficits, especially over time and in the elderly, weight gain, as well as abnormal kidney function. After acute injections of propranolol over a 7-day period, subjects will be exposed to a noninvasive blood pressure machine, urinalysis, as well as a radial arm maze to test for cognitive deficits. The purpose of my study is to investigate, the overall positive and negative effects of the beta- blocker propranolol on the body, specifically on blood pressure, body weight and kidney function.
Included in
The Pharmacological and Cognitive Effects of Propranolol on CD-1 Mice
The Pharmacological and Cognitive Effects of Propranolol on CD-1 Mice Jennifer Hindieh, William Hoefer, Grace Rossi, Christopher McAllister Long Island University Post Campus, Psychology Department, College of Liberal Arts & Sciences Currently, 31 million people in the United States have chronic kidney disease; with high blood pressure being the 2nd leading cause of kidney disease, and about 70 million people in the United States have high blood pressure. The importance of studying the conditions becomes more prevalent as the average individual, of recent times, has a diet consisting of preservatives, artificial ingredients, which in turn leads to a more consistent weight gain over time. For years medical professionals have recommended not only a complete lifestyle change for those that suffer from the aforementioned conditions, but have also prescribed beta-blockers for an even more effective control of high blood pressure. According to Consumer Reports, Propranolol is the 3rd most prescribed beta- blocker in the United States, even though many researchers concluded that the full physiological and cognitive effects are still widely unknown for such a heavily prescribed medication. While the blood pressure benefits of propranolol are for certain, other negative side effects have been reported but not widely studied such as severe cognitive deficits, especially over time and in the elderly, weight gain, as well as abnormal kidney function. After acute injections of propranolol over a 7-day period, subjects will be exposed to a noninvasive blood pressure machine, urinalysis, as well as a radial arm maze to test for cognitive deficits. The purpose of my study is to investigate, the overall positive and negative effects of the beta- blocker propranolol on the body, specifically on blood pressure, body weight and kidney function.