Investigating the Neuroprotective Effects of Flavonoids on Oxidative Stress, Tau Pathology, and Beta Amyloid Aggregation in Alzheimer’s Disease: A Systematic Literature Review

Faculty Mentor

Kenza Benzeroual

Major/Area of Research

Pharmacy/Complementary Alternative Medicine

Description

INTRODUCTION: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is prevalent among older adults, characterized by cognitive decline, memory loss, and behavioral changes.

RESULTS: Although the pathological mechanisms of AD remain complex and unclear, key features include extracellular neuritic plaques composed of amyloid beta peptides and intracellular neurofibrillary tangles that contain hyper-phosphorylated tau proteins- which play a significant role in causing neuronal dysfunction.

CONCLUSION: Current treatments provide limited symptomatic relief without halting the progression of this disease.

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Investigating the Neuroprotective Effects of Flavonoids on Oxidative Stress, Tau Pathology, and Beta Amyloid Aggregation in Alzheimer’s Disease: A Systematic Literature Review

INTRODUCTION: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is prevalent among older adults, characterized by cognitive decline, memory loss, and behavioral changes.

RESULTS: Although the pathological mechanisms of AD remain complex and unclear, key features include extracellular neuritic plaques composed of amyloid beta peptides and intracellular neurofibrillary tangles that contain hyper-phosphorylated tau proteins- which play a significant role in causing neuronal dysfunction.

CONCLUSION: Current treatments provide limited symptomatic relief without halting the progression of this disease.