Evaluation of Changes in Gut Microbiota and its Effects on Insulin Sensitivity and Blood Glucose
Faculty Mentor
Xinyi Huang
Major/Area of Research
Pharmacy
Description
INTRODUCTION: Insulin sensitivity and impaired blood glucose control are known precursors to type 2 diabetes mellitus. Recently, the alterations in gut microbiota have been studied more extensively and have been shown to have an active role in regulating metabolism. The intestine is responsible for relaying both peripheral and central signals to the body that regulate blood insulin levels, such as branched-chain amino acids (BCAAs), affecting blood glucose levels as well. Changes in gut microbiome may contribute to the current state of metabolic disorders.
METHOD: A systematic review was conducted in Medline/Pubmed for studies evaluating gut microbiome as drug metabolizer in human population. A total of 2073 studies in English were assessed. The exploration of mechanisms in which alterations in gut microbiota have affected insulin sensitivity were focused on in ten studies included for qualitative review.
CONCLUSION: The exploration in this association offers alternative therapies in patients who have uncontrolled blood glucose or type 2 diabetes. Analyzing the effects of gut microbiota may help health care providers understand and personalize therapy in these individuals.
Evaluation of Changes in Gut Microbiota and its Effects on Insulin Sensitivity and Blood Glucose
INTRODUCTION: Insulin sensitivity and impaired blood glucose control are known precursors to type 2 diabetes mellitus. Recently, the alterations in gut microbiota have been studied more extensively and have been shown to have an active role in regulating metabolism. The intestine is responsible for relaying both peripheral and central signals to the body that regulate blood insulin levels, such as branched-chain amino acids (BCAAs), affecting blood glucose levels as well. Changes in gut microbiome may contribute to the current state of metabolic disorders.
METHOD: A systematic review was conducted in Medline/Pubmed for studies evaluating gut microbiome as drug metabolizer in human population. A total of 2073 studies in English were assessed. The exploration of mechanisms in which alterations in gut microbiota have affected insulin sensitivity were focused on in ten studies included for qualitative review.
CONCLUSION: The exploration in this association offers alternative therapies in patients who have uncontrolled blood glucose or type 2 diabetes. Analyzing the effects of gut microbiota may help health care providers understand and personalize therapy in these individuals.